Lipase-catalyzed solvent-free kinetic resolution of substituted racemic ε-caprolactones

被引：23

作者：

Kondaveti, L ^{[1
]}

Al-Azemi, TF ^{[1
]}

Bisht, KS ^{[1
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(02)00064-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The kinetic resolution of racemic seven-membered lactones is reported, for the first time in bulk (solvent-free) conditions, by lipase-catalysed butanolysis. The lactones studied were substituted at either the 4- or the 6-position. With these lactones, Novozym-435 lipase (from Candida antarctica) induced (S)-selective butanololysis, and (R)-lactones were recovered unreacted with >97% enantiomeric excess (e.e.). The reactions were studied at different reaction temperatures, viz. 0, 23, 40 and 60degreesC. A comparative study of the effect of temperature on the kinetic resolution is presented. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：129 / 135

页数：7

共 47 条

[41] ANOMALOUS TEMPERATURE DEPENDENCE OF ENZYME-CATALYZED REACTIONS [J].