Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases

被引：45

作者：

Ben Hmidene, Asma ^{[1
]}

Hanaki, Mizuho ^{[2
]}

Murakami, Kazuma ^{[2
]}

Irie, Kazuhiro ^{[2
]}

Isoda, Hiroko ^{[3
,4
]}

Shigemori, Hideyuki ^{[4
]}

机构：

[1] Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan

[2] Kyoto Univ, Grad Sch Biostudies, Sakyo Ku, Kyoto 6068502, Japan

[3] Univ Tsukuba, Alliance Res North Africa ARENA, Tsukuba, Ibaraki 3058572, Japan

[4] Univ Tsukuba, Fac Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2017年 / 40卷 / 02期

基金：

日本学术振兴会;

关键词：

amyloid aggregation; glucuronosylated flavonoid; Tamarix gallica; Alzheimer's disease; type; 2; diabetes; BETA AGGREGATION; PROTEIN; CONSTITUENTS;

D O I：

10.1248/bpb.b16-00801

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The prevention of amyloid aggregation is promising for the treatment of age-related diseases such as Alzheimer's (AD) and type 2 diabetes (T2D). Ten antioxidant flavonoids isolated from the medicinal halophyte Tamarix gallica were tested for their amyloid aggregation inhibition potential. Glucuronosylated flavonoids show relatively strong inhibitory activity of Amyloid beta (A beta) and human islet amyloid polypeptide (hIAPP) aggregation compared to their aglycone analogs. Structure-activity relationship of the flavonoids suggests that the catechol moiety is important for amyloid aggregation inhibition, while the methylation of the carboxyl group in the glucuronide moiety and of the hydroxyl group in the aglycone flavonoids decreased it.

引用

收藏

页码：238 / 241

页数：4

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