antigen presentation;
B lymphocytes;
dendritic cells;
Fc receptors;
immune complexes;
D O I:
10.1006/smim.1999.0196
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Antigens internalized through specific membrane receptors are presented to helper CD4+ T cells antigen concentrations 10(3) to 10(4) fold lower than antigens internalized by fluid phase. B lymphocyte antigen receptors, mannose receptors and receptors for the Fc region of immunoglobulins promote both internalization and immunoglobulins, low antigen concentration. Thus, binding to specific membrane receptors concentrate antigens on antigen presenting cells and mediates efficient uptake. Is this 'quantitative' concentration of antigens on antigen presenting cells the end of the story? Or may 'quality', i.e. selective intracellular antigen targeting, somehow influence the efficiency or specificity of MHC class I and class II-restricted antigen presentation?
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Bennett, SRM
Carbone, FR
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机构:
PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, AustraliaPO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Carbone, FR
Karamalis, F
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机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Karamalis, F
Flavell, RA
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机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Flavell, RA
Miller, JFAP
论文数: 0引用数: 0
h-index: 0
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Miller, JFAP
Heath, WR
论文数: 0引用数: 0
h-index: 0
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Bennett, SRM
Carbone, FR
论文数: 0引用数: 0
h-index: 0
机构:
PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, AustraliaPO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Carbone, FR
Karamalis, F
论文数: 0引用数: 0
h-index: 0
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Karamalis, F
Flavell, RA
论文数: 0引用数: 0
h-index: 0
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Flavell, RA
Miller, JFAP
论文数: 0引用数: 0
h-index: 0
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia
Miller, JFAP
Heath, WR
论文数: 0引用数: 0
h-index: 0
机构:PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia