Enzymatic catalysis of the Diels-Alder reaction in the biosynthesis of natural products

被引：217

作者：

Oikawa, H ^{[1
]}

Tokiwano, T ^{[1
]}

机构：

[1] Hokkaido Univ, Div Chem, Grad Sch Sci, Kita Ku, Sapporo, Hokkaido 0600810, Japan

来源：

NATURAL PRODUCT REPORTS | 2004年 / 21卷 / 03期

关键词：

D O I：

10.1039/b305068h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies on enzymes catalyzing the Diels-Alder reaction, often named "Diels-Alderases", clearly demonstrated the involvement of this synthetically useful reaction in the biosynthesis of natural products. This review covers natural Diels-Alder type cycloadducts, synthetic efforts on the chemical feasibility of the biosynthetic Diels-Alder reaction and a brief history of studies on Diels-Alderases. In addition, reaction mechanisms of artificial and natural Diets-Alderases are discussed.

引用

页码：321 / 352

页数：32

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