Mechanisms of Disease: Scleroderma.

被引:1175
作者
Gabrielli, Armando [1 ,2 ]
Avvedimento, Enrico V. [3 ]
Krieg, Thomas [4 ]
机构
[1] Univ Politecn Marche, Sect Clin Med, Dept Med Sci & Surg, Ancona, Italy
[2] Osped Riuniti, Ancona, Italy
[3] Univ Naples Federico II, CNR, Inst Endocrinol & Expt Oncol, Dept Mol & Cellular Biol & Pathol, Naples, Italy
[4] Univ Cologne, Dept Dermatol, D-5000 Cologne, Germany
关键词
GROWTH-FACTOR-BETA; PROGRESSIVE SYSTEMIC-SCLEROSIS; ENDOTHELIAL PROGENITOR CELLS; OXYGEN SPECIES PRODUCTION; NADPH OXIDASE COMPLEX; REACTIVE OXYGEN; TGF-BETA; INCREASED EXPRESSION; UP-REGULATION; IN-VITRO;
D O I
10.1056/NEJMra0806188
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:1989 / 2003
页数:15
相关论文
共 108 条
  • [91] Radical oxygen species production induced by advanced oxidation protein products predicts clinical evolution and response to treatment in systemic sclerosis
    Servettaz, A.
    Guilpain, P.
    Goulvestre, C.
    Chereau, C.
    Hercend, C.
    Nicco, C.
    Guillevin, L.
    Weill, B.
    Mouthon, L.
    Batteux, F.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (09) : 1202 - 1209
  • [92] Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma
    Sgonc, R
    Gruschwitz, MS
    Dietrich, H
    Recheis, H
    Gershwin, ME
    Wick, G
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (03) : 785 - 792
  • [93] Dissecting the roles of endothelin, TGF-β and GM-CSF on myofibroblast differentiation by keratinocytes
    Shephard, P
    Hinz, B
    Smola-Hess, S
    Meister, JJ
    Krieg, T
    Smola, H
    [J]. THROMBOSIS AND HAEMOSTASIS, 2004, 92 (02) : 262 - 274
  • [94] CUTANEOUS HYPOXIA IN PATIENTS WITH SYSTEMIC-SCLEROSIS (SCLERODERMA)
    SILVERSTEIN, JL
    STEEN, VD
    MEDSGER, TA
    FALANGA, V
    [J]. ARCHIVES OF DERMATOLOGY, 1988, 124 (09) : 1379 - 1382
  • [95] SNAPPER CM, 1993, J IMMUNOL, V151, P4625
  • [96] Sondergaard K, 1998, BRIT J RHEUMATOL, V37, P304
  • [97] Postnatal induction of transforming growth factor β signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma
    Sonnylal, Sonali
    Denton, Christopher P.
    Zheng, Bing
    Keene, Douglas R.
    He, Ruming
    Adams, Henry P.
    VanPelt, Carolyn S.
    Geng, Yong J.
    Deng, Jenny M.
    Behringer, Richard R.
    de Crombrugghe, Benoit
    [J]. ARTHRITIS AND RHEUMATISM, 2007, 56 (01): : 334 - 344
  • [98] Stellos K, 2008, PHARMACOL REP, V60, P101
  • [99] Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells
    Stellos, Konstantinos
    Langer, Harald
    Daub, Karin
    Schoenberger, Tanja
    Gauss, Alexandra
    Geisler, Tobias
    Bigalke, Boris
    Mueller, Iris
    Schumm, Michael
    Schaefer, Iris
    Seizer, Peter
    Kraemer, Bjoern F.
    Siegel-Axel, Dorothea
    May, Andreas E.
    Lindemann, Stephan
    Gawaz, Meinrad
    [J]. CIRCULATION, 2008, 117 (02) : 206 - 215
  • [100] Transforming growth factor-β1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells
    Sturrock, A
    Cahill, B
    Norman, K
    Huecksteadt, TP
    Hill, K
    Sanders, K
    Karwande, SV
    Stringham, JC
    Bull, DA
    Gleich, M
    Kennedy, TP
    Hoidal, JR
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2006, 290 (04) : L661 - L673