Genome-wide patterns of histone modifications in yeast

被引：225

作者：

Millar, Catherine B. ^{[1
]}

Grunstein, Michael

机构：

[1] Univ Calif Los Angeles, Dept Biol Chem, Geffen Sch Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 09期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrm1986

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Post-translational histone modifications and histone variants generate complexity in chromatin to enable the many functions of the chromosome. Recent studies have mapped histone modifications across the Saccharomyces cerevisiae genome. These experiments describe how combinations of modified and unmodified states relate to each other and particularly to chromosomal landmarks that include heterochromatin, subtelomeric chromatin, centromeres, origins of replication, promoters and coding regions. Such patterns might be important for the regulation of heterochromatin-mediated silencing, chromosome segregation, DNA replication and gene expression.

引用

页码：657 / 666

页数：10

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