Antidepressant treatment of depression: A metaanalysis

被引：86

作者：

Joffe, R ^{[1
]}

Sokolov, S ^{[1
]}

Streiner, D ^{[1
]}

机构：

[1] MCMASTER UNIV,DEPT CLIN EPIDEMIOL & BIOSTAT,HAMILTON,ON L8N 3Z5,CANADA

来源：

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE | 1996年 / 41卷 / 10期

关键词：

depression; metaanalysis; antidepressant;

D O I：

10.1177/070674379604101002

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: To carry out a metaanalysis of antidepressant studies to calculate the effect sizes for antidepressant effect in depressive disorder. Method: A metaanalysis of all antidepressant studies that included an active comparison drug as well as placebo was used to calculate the effect size. Articles were selected from a MEDLINE search for the period January 1966 to June 1995. Forty-nine studies were included in the metaanalysis. Results: The effect sizes for antidepressant treatment are moderately larger than for placebo. A larger effect size was observed in studies where objective diagnostic criteria for depression were used. Conclusions: We conclude that the superior efficacy of antidepressants over placebo can be demonstrated.

引用

页码：613 / 616

页数：4