APTIMA® transcription-mediated amplification assays for Chlamydia trachomatis and Neisseria gonorrhoeae

被引：25

作者：

Chernesky, Max A. ^{[1
]}

Jang, Dan E. ^{[1
]}

机构：

[1] McMaster Univ, St Josephs Healthcare, Hamilton, ON L8N 4A6, Canada

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2006年 / 6卷 / 04期

关键词：

analytical sensitivity; APTIMA (R); automation; Chlamydia trachomatis; clinical sensitivity; inhibitor; Neisseria gonorrhoeae; noninvasive specimen; nucleic acid; transcription-mediated amplification;

D O I：

10.1586/14737159.6.4.519

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The APTIMA(R) transcription-mediated amplification assays for Chlamydia trachomatis and Neisseria gonorrhoeae have the greatest sensitivity of all the commercial nucleic acid amplification tests for the diagnosis of infections from noninvasive samples that may contain small amounts of nucleic acid. They have received extensive attention in male and female populations of varying prevalences of infection. Vulvovaginal swabs appear to be the specimen of choice (either self-collected or physician collected) in women and first-catch urine in men. Gen-Probe Inc. has created alternate amplification primers for confirmatory or initial single organism testing. With automation of the TIGRIS(R) instrument, the assays should prove to be useful in high-volume laboratories.

引用

页码：519 / 525

页数：7

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