Chasing the treasures of the sea - bacterial marine natural products

被引：95

作者：

Gulder, Tobias A. M.

Moore, Bradley S. ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2009年 / 12卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ACTINOMYCETE SALINISPORA-TROPICA; HISTONE DEACETYLASE INHIBITOR; IMAGING MASS-SPECTROMETRY; GENE-CLUSTER; HETEROLOGOUS EXPRESSION; PROTEASOME INHIBITORS; METABOLITE PRODUCTION; SALINOSPORAMIDE-A; DRUG DISCOVERY; 20S PROTEASOME;

D O I：

10.1016/j.mib.2009.05.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacterial marine natural products are an important source of novel lead structures for drug discovery. The cytotoxic properties of many of these secondary metabolites are of particular interest for the development of new anticancer agents. Tremendous advances in marine molecular biology, genome sequencing, and bioinformatics have paved the way to fully exploit the biomedical potential of marine bacterial products. In addition, unique biosynthetic enzymes discovered from bacteria from the sea have begun to emerge as powerful biocatalysts in medicinal chemistry and total synthesis. The increasingly interdisciplinary field of marine natural product chemistry thus strongly impacts future developments in medicine, chemistry, and biology.

引用

页码：252 / 260

页数：9

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