Marineosins A and B, Cytotoxic Spiroaminals from a Marine-Derived Actinomycete

被引：90

作者：

Boonlarppradab, Chollaratt ^{[1
]}

Kauffman, Christopher A. ^{[1
]}

Jensen, Paul R. ^{[1
]}

Fenical, William ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 24期

关键词：

D O I：

10.1021/ol8020644

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel spiroaminals, marineosins A and B (1, 2), containing two pyrrole functionalities, were isolated from cultures of a marine sediment-derived actinomycete related to the genus Streptomyces. The marineosins, which appear to be derived from unknown modifications of prodigiosin-like pigment pathways, showed significant inhibition of human colon carcinoma (HCT-116) in an in vitro assay (IC50 = 0.5 mu M for marineosin A) and selective activities in diverse cancer cell types.

引用

页码：5505 / 5508

页数：4

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