Multivalent dendrons for high-affinity adhesion of proteins to DNA

被引：61

作者：

Kostiainen, Mauri A.

Szilvay, Geza R.

Smith, David K.

Linder, Markus B.

Ikkala, Olli

机构：

[1] Aalto Univ, Dept Engn Phys & Math, Espoo 02015, Finland

[2] Aalto Univ, Ctr New Mat, Espoo 02015, Finland

[3] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[4] Univ Helsinki, Inst Biotechnol, Res Program Struct Biol & Biophys, FIN-00014 Helsinki, Finland

[5] VTT Biotechnol, FIN-02044 Helsinki, Finland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 21期

关键词：

dendrimers; DNA; multivalency; protein modifications; self-assembly;

D O I：

10.1002/anie.200504540

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Strength in numbers: Multivalent dendrons that have an N-maleimido group at the focal point can be used to construct monodisperse one-to-one protein-dendron conjugates. The second generation polyamine dendron with spermine surface groups clearly imparts its high-affinity DNA binding to a protein of choice. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3538 / 3542

页数：5

共 35 条

[1] Rational design of a potent, long-lasting form of interferon:: A 40 kDa branched polyethylene glycol-conjugated interferon α-2a for the treatment of hepatitis C [J].