Ethanol withdrawal in rats is attenuated by intracerebroventricular administration of neuropeptide Y

被引：33

作者：

Woldbye, DPD ^{[1
]}

Ulrichsen, J ^{[1
]}

Haugbol, S ^{[1
]}

Bolwig, TG ^{[1
]}

机构：

[1] Univ Copenhagen, Rigshosp, Lab Neuropsychiat,Dept Psychiat, Dept Pharmacol, DK-2100 Copenhagen, Denmark

来源：

ALCOHOL AND ALCOHOLISM | 2002年 / 37卷 / 04期

关键词：

D O I：

10.1093/alcalc/37.4.318

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Aims: The effects of intracerebroventricular administration of neuropeptide Y (NPY) on ethanol withdrawal were studied in rats. Methods: Ethanol was administered intragastrically five times daily for 4 days. At 16-17 h after the last infusion of ethanol, rats were rated for withdrawal using a score based on three signs: irritability, tremor and rigidity. Subsequently, the rats received an injection of NPY (12 or 24 nmol) or vehicle and were rated for signs of withdrawal. Results: At both doses, NPY significantly reduced ethanol withdrawal, the effect of the larger dose being more pronounced. Conclusions: Our results are consistent with the concept that NPY receptors are centrally involved in the regulation of neuronal excitability and might form a novel therapeutic target for treatment of ethanol withdrawal and other states of neuronal hyperexcitability.

引用

页码：318 / 321

页数：4

共 38 条

[1] OPIATE WITHDRAWAL INCREASES GLUTAMATE AND ASPARTATE EFFLUX IN THE LOCUS-COERULEUS - AN IN-VIVO MICRODIALYSIS STUDY [J].