The association of Tap42 phosphatase complexes with TORC1 - Another level of regulation in tor signaling

被引:15
作者
Di Como, Charles J.
Jiang, Yu
机构
[1] Univ Pittsburgh, Sch Med, Dept Pharmacol, Pittsburgh, PA 15213 USA
[2] Aureon Labs Inc, Yonkers, NY USA
关键词
Tap42; rapamycin; Tor kinases; PP2A; Sit4;
D O I
10.4161/cc.5.23.3516
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In the budding yeast Saccharomyces cerevisiae, rapamycin has been known to induce a rapid dephosphorylation of many downstream targets of Tor. The key components mediating this dephosphorylation process are the Tap42-associated phosphatases, which become active upon rapamycin treatment. However, the mechanism by which rapamycin rapidly activates phosphatases is unclear. A recent report has provided evidence demon strating a physical association of the Tap42-phosphatase complexes with TORC1, which is sensitive to rapamycin treatment or nutrient starvation. This association adds another level of regulation in Tor signaling, and explains why rapamycin or nutrient availability is able to initiate a rapid and robust response in the cell.
引用
收藏
页码:2729 / 2732
页数:4
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