Elucidating TOR signaling and rapamycin action:: lessons from Saccharomyces cerevisiae

被引：291

作者：

Crespo, JL ^{[1
]}

Hall, MN ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, Div Biochem, CH-4056 Basel, Switzerland

来源：

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS | 2002年 / 66卷 / 04期

关键词：

D O I：

10.1128/MMBR.66.4.579-591.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function.

引用

页码：579 / +

页数：14

共 171 条

[1] Autophagy in yeast: Mechanistic insights and physiological function
Abeliovich, H
Klionsky, DJ
[J]. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2001, 65 (03) : 463 - +
[2] Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham, RT
[J]. GENES & DEVELOPMENT, 2001, 15 (17) : 2177 - 2196
[3] Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast
Alarcon, CM
Heitman, J
Cardenas, ME
[J]. MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (08) : 2531 - 2546
[4] The target of rapamycin signaling pathway regulates mRNA turnover in the yeast Saccharomyces cerevisiae
Albig, AR
Decker, CJ
[J]. MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (11) : 3428 - 3438
[5] HEAT REPEATS IN THE HUNTINGTONS-DISEASE PROTEIN
ANDRADE, MA
BORK, P
[J]. NATURE GENETICS, 1995, 11 (02) : 115 - 116
[6] Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3' untranslated region
Banholzer, R
Nair, APK
Hirsch, HH
Ming, XF
Moroni, C
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (06) : 3254 - 3260
[7] TOR controls translation initiation and early G1 progression in yeast
Barbet, NC
Schneider, U
Helliwell, SB
Stansfield, I
Tuite, MF
Hall, MN
[J]. MOLECULAR BIOLOGY OF THE CELL, 1996, 7 (01) : 25 - 42
[8] Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast
Beck, T
Schmidt, A
Hall, MN
[J]. JOURNAL OF CELL BIOLOGY, 1999, 146 (06) : 1227 - 1237
[9] The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
Beck, T
Hall, MN
[J]. NATURE, 1999, 402 (6762) : 689 - 692
[10] Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation
Beretta, L
Gingras, AC
Svitkin, YV
Hall, MN
Sonenberg, N
[J]. EMBO JOURNAL, 1996, 15 (03) : 658 - 664

← 1 2 3 4 5 6 7 8 9 10 →