Elucidating TOR signaling and rapamycin action:: lessons from Saccharomyces cerevisiae

被引：291

作者：

Crespo, JL ^{[1
]}

Hall, MN ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, Div Biochem, CH-4056 Basel, Switzerland

来源：

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS | 2002年 / 66卷 / 04期

关键词：

D O I：

10.1128/MMBR.66.4.579-591.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function.

引用

页码：579 / +

页数：14

共 171 条

[21] RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
Burnett, PE
Barrow, RK
Cohen, NA
Snyder, SH
Sabatini, DM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) : 1432 - 1437
[22] DOMINANT MISSENSE MUTATIONS IN A NOVEL YEAST PROTEIN RELATED TO MAMMALIAN PHOSPHATIDYLINOSITOL 3-KINASE AND VPS34 ABROGATE RAPAMYCIN CYTOTOXICITY
CAFFERKEY, R
YOUNG, PR
MCLAUGHLIN, MM
BERGSMA, DJ
KOLTIN, Y
SATHE, GM
FAUCETTE, L
ENG, WK
JOHNSON, RK
LIVI, GP
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (10) : 6012 - 6023
[23] Glutamine and the immune system
Calder, PC
Yaqoob, P
[J]. AMINO ACIDS, 1999, 17 (03) : 227 - 241
[24] The TOR signaling cascade regulates gene expression in response to nutrients
Cardenas, ME
Cutler, NS
Lorenz, MC
Di Como, CJ
Heitman, J
[J]. GENES & DEVELOPMENT, 1999, 13 (24) : 3271 - 3279
[25] Phosphorylation regulates the interaction between Gln3p and the nuclear import factor Srp1p
Carvalho, J
Bertram, PG
Wente, SR
Zheng, XFS
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (27) : 25359 - 25365
[26] Remodeling of yeast genome expression in response to environmental changes
Causton, HC
Ren, B
Koh, SS
Harbison, CT
Kanin, E
Jennings, EG
Lee, TI
True, HL
Lander, ES
Young, RA
[J]. MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (02) : 323 - 337
[27] IDENTIFICATION OF AN 11-KDA FKBP12-RAPAMYCIN-BINDING DOMAIN WITHIN THE 289-KDA FKBP12-RAPAMYCIN-ASSOCIATED PROTEIN AND CHARACTERIZATION OF A CRITICAL SERINE RESIDUE
CHEN, J
ZHENG, XF
BROWN, EJ
SCHREIBER, SL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) : 4947 - 4951
[28] α4 associates with protein phosphatases 2A, 4, and 6
Chen, J
Peterson, RT
Schreiber, SL
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 247 (03) : 827 - 832
[29] RAPT1, A MAMMALIAN HOMOLOG OF YEAST TOR, INTERACTS WITH THE FKBP12 RAPAMYCIN COMPLEX
CHIU, MI
KATZ, H
BERLIN, V
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (26) : 12574 - 12578
[30] CHOI JP, 1996, EUROPEAN J POLITICAL, V12, P273, DOI DOI 10.1016/0176-2680(95)00017-8

← 1 2 3 4 5 6 7 8 9 10 →