Elucidating TOR signaling and rapamycin action:: lessons from Saccharomyces cerevisiae

被引：291

作者：

Crespo, JL ^{[1
]}

Hall, MN ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, Div Biochem, CH-4056 Basel, Switzerland

来源：

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS | 2002年 / 66卷 / 04期

关键词：

D O I：

10.1128/MMBR.66.4.579-591.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function.

引用

页码：579 / +

页数：14

共 171 条

[41] Mammalian TOR: A homeostatic ATP sensor
Dennis, PB
Jaeschke, A
Saitoh, M
Fowler, B
Kozma, SC
Thomas, G
[J]. SCIENCE, 2001, 294 (5544) : 1102 - 1105
[42] Dennis PB, 1996, MOL CELL BIOL, V16, P6242
[43] Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation
Dennis, PB
Fumagalli, S
Thomas, G
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1999, 9 (01) : 49 - 54
[44] Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
DiComo, CJ
Arndt, KT
[J]. GENES & DEVELOPMENT, 1996, 10 (15) : 1904 - 1916
[45] Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S-cerevisiae
Dilova, I
Chen, CY
Powers, T
[J]. CURRENT BIOLOGY, 2002, 12 (05) : 389 - 395
[46] Phosphatidic acid-mediated mitogenic activation of mTOR signaling
Fang, YM
Vilella-Bach, M
Bachmann, R
Flanigan, A
Chen, J
[J]. SCIENCE, 2001, 294 (5548) : 1942 - 1945
[47] FERRARI S, 1993, J BIOL CHEM, V268, P16091
[48] The Cln3 cyclin is down-regulated by translational repression and degradation during the G1 arrest caused by nitrogen deprivation in budding yeast
Gallego, C
Garí, E
Colomina, N
Herrero, E
Aldea, M
[J]. EMBO JOURNAL, 1997, 16 (23) : 7196 - 7206
[49] Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p
Gasch, AP
Huang, MX
Metzner, S
Botstein, D
Elledge, SJ
Brown, PO
[J]. MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (10) : 2987 - 3003
[50] Regulation of translation initiation by FRAP/mTOR
Gingras, AC
Raught, B
Sonenberg, N
[J]. GENES & DEVELOPMENT, 2001, 15 (07) : 807 - 826

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