Microwave assisted green chemical synthesis of novel spiro[indole-pyrido thiazines]: a system reluctant to be formed under thermal conditions

被引：60

作者：

Dandia, A ^{[1
]}

Arya, K ^{[1
]}

Sati, M ^{[1
]}

Gautam, S ^{[1
]}

机构：

[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India

来源：

TETRAHEDRON | 2004年 / 60卷 / 24期

关键词：

pyrido thiazine; microwave irradiation;

D O I：

10.1016/j.tet.2004.04.018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Spiro [3H-indole-3,2'-[4H] pyrido [3,2-e]-1,3-thiazine]-2,4' (1H) diones, a class of previously unknown compound which does not form under conventional conditions, can be prepared by treatment of 'in situ' generated 3-indolylimine derivatives with 2-mercaptonicotinic acid under microwave irradiation in absence of any solvent or solid support in 85-92% yields in 3-8 min. The facile one pot reaction is generalized for a variety of ketones and amines to give pure pyrido [3,2-e] thiazine derivatives, which do not require further purification processes. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5253 / 5258

页数：6

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