The relationship between mitochondrial shape and function and the cytoskeleton

被引：228

作者：

Anesti, Vasiliki ^{[1
]}

Scorrano, Luca ^{[1
]}

机构：

[1] Venetian Inst Mol Med, Dulbecco Telethon Inst, I-35129 Padua, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2006年 / 1757卷 / 5-6期

关键词：

mitochondria; fusion; fission; cytoskeleton; motility; kinesin; dynein; trichoplein;

D O I：

10.1016/j.bbabio.2006.04.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are crucial organelles for life and death of the cell. They are prominent players in energy conversion and integrated signaling pathways including regulation of Ca2+ signals and apoptosis. Their functional versatility is matched by their morphological plasticity and by their high mobility, allowing their transport at specialized cellular sites. This transport occurs by interactions with a variety of cytoskeletal proteins that also have the ability to influence shape and function of the organelle. A growing body of evidence suggests that mitochondria use cytoskeletal proteins as tracks for their movement; in turn, mitochondrial morphology and function is regulated via mostly uncharacterized pathways, by the cytoskeleton. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：692 / 699

页数：8

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