New treatments for COPD

被引：101

作者：

Barnes, PJ ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Sch Med, London SW3 6LY, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 06期

关键词：

D O I：

10.1038/nrd820

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

COPD is one of the most common diseases in the world, and there is a global increase in prevalence, but there are no drugs available at present that halt the relentless progression of this disease. However, a better understanding of the cellular and molecular mechanisms that are involved in the underlying inflammatory and destructive processes has revealed several new targets for which drugs are now in development, and the prospects for finding new treatments are good.

引用

页码：437 / 446

页数：10

共 93 条

[51] Thiol-dependent enzymes and their inhibitors: A review [J].

Leung-Toung, R ;

Li, WR ;

Tam, TF ;

Karimian, K .

CURRENT MEDICINAL CHEMISTRY, 2002, 9 (09) :979-1002

[52] Long-acting bronchodilation with once-daily dosing of tiotropium (Spiriva) in stable chronic obstructive pulmonary disease [J].

Littner, MR ;

Ilowite, JS ;

Tashkin, DP ;

Friedman, M ;

Serby, CW ;

Menjoge, SS ;

Witek, TJ .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (04) :1136-1142

[53] The global burden of disease, 1990-2020 [J].

Lopez, AD ;

Murray, CCJL .

NATURE MEDICINE, 1998, 4 (11) :1241-1243

[54] Oxidants/antioxidants and COPD [J].

MacNee, W .

CHEST, 2000, 117 (05) :303S-317S

[55] A pilot study of all-trans-retinoic acid for the treatment of human emphysema [J].

Mao, JT ;

Goldin, JG ;

Dermand, J ;

Ibrahim, G ;

Brown, MS ;

Emerick, A ;

McNitt-Gray, MF ;

Gjertson, DW ;

Estrada, F ;

Tashkin, DP ;

Roth, MD .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 165 (05) :718-723

[56] Infliximab - A review of its use in the management of rheumatoid arthritis [J].

Markham, A ;

Lamb, HM .

DRUGS, 2000, 59 (06) :1341-1359

[57] Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats [J].

Massaro, GD ;

Massaro, D .

NATURE MEDICINE, 1997, 3 (06) :675-677

[58]

Meagher LC, 1996, J IMMUNOL, V156, P4422

[59] p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-κB-independent mechanism [J].

Meja, KK ;

Seldon, PM ;

Nasuhara, Y ;

Ito, K ;

Barnes, PJ ;

Lindsay, MA ;

Giembycz, MA .

BRITISH JOURNAL OF PHARMACOLOGY, 2000, 131 (06) :1143-1153

[60] Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers [J].

Montuschi, P ;

Collins, JV ;

Ciabattoni, G ;

Lazzeri, N ;

Corradi, M ;

Kharitonov, SA ;

Barnes, PJ .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (03) :1175-1177

← 1 2 3 4 5 6 7 8 9 10 →