Evolution of arylalkylamine N-acetyltransferase:: Emergence and divergence

被引:70
作者
Coon, Steven L. [1 ]
Klein, David C. [1 ]
机构
[1] NICHHD, Sect Neuroendocrinol, Off Sci Director, NIH, Bethesda, MD 20894 USA
关键词
arylalkylamine N-acetyltransferase; AANAT; evolution; melatonin;
D O I
10.1016/j.mce.2006.03.039
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The melatonin rhythm-generating enzyme, arylalkylarnine N-acetyltransferase (AANAT) is known to have recognizable ancient homologs in bacteria and fungi, but not in other eukaryotes. Analysis of new cDNA and genomic sequences has identified several additional homologs in other groupings. First, an AANAT homolog has been found in the genome of the cephalochordate amphioxus, representing the oldest homolog in chordates. Second, two AANAT homologs have been identified in unicellular green algae. The homologs in amphioxus, unicellular green algae, fungi and bacteria are similarly primitive in that they lack sequences found in vertebrate AANATs that are involved in regulation and that facilitate binding and catalysis. In addition, all these sequences are intronless. These features are consistent with horizontal transfer of the AANAT ancestor from bacteria to green algae, fungi and chordates. Lastly, a third AANAT gene has been found in teleost fish, suggesting that AANAT genes serve multiple functions in addition to melatonin synthesis. Published by Elsevier Ireland Ltd
引用
收藏
页码:2 / 10
页数:9
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