Anticancer and antithrombin activity of Russian plants

被引：80

作者：

Goun, EA

Petrichenko, VM

Solodnikov, SU

Suhinina, TV

Kline, MA

Cunningham, G

Nguyen, C

Miles, H ^{[1
]}

机构：

[1] Univ Cent Florida, Dept Chem, Orlando, FL 32826 USA

[2] Perm State Pharmaceut Acad, Perm 614000, Russia

[3] Perm State Univ, Perm 614000, Russia

[4] Univ Cent Florida, Ctr Drug Discovery & Diagnost, Orlando, FL 32826 USA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2002年 / 81卷 / 03期

关键词：

antithrombin activity; anticancer activity; mouse leukemia (L1210); Russian plants; Quercus robur; Sanguisorba officinalis;

D O I：

10.1016/S0378-8741(02)00116-2

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A chromogenic bioassay was utilized to determine the antithrombin activity of the methylene chloride and methanol extracts prepared from forty-five plants of Russia. Mouse leukemia cells (L1210) were utilized to screen these extracts for activity against cancer. The results indicated that eight plant extracts demonstrated 90% or higher activity in the inhibition of thrombin. Also, nine methanol extracts demonstrated activity of 90% or higher in the inhibition of mouse leukemia L1210 cells. The methanol extracts of Quercus robur and Sanguisorba afficinalis demontrated high activity against both thrombin and cancer. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：337 / 342

页数：6

共 41 条

[21] Screening of several Indonesian medicinal plants for their inhibitory effect on histamine release from RBL-2H3 cells [J].