Current status of artificial oxygen carriers

被引:54
作者
Spahn, DR [1 ]
机构
[1] Univ Zurich Hosp, Inst Anasthesiol, CH-8091 Zurich, Switzerland
关键词
artificial oxygen carriers; oxygen transport; hemoglobin solutions; fluorocarbon emulsion; perflubron;
D O I
10.1016/S0169-409X(99)00046-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Artificial oxygen carriers may be grouped into modified hemoglobin solutions and fluorocarbon emulsions. In animal experiments, both have been shown to be efficacious in improving tissue oxygenation and as substitutes for blood transfusions. Advantages and disadvantages are being discussed in this article as well as the latest steps in the clinical development. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:143 / 151
页数:9
相关论文
共 51 条
[1]   The use of diaspirin crosslinked hemoglobin (DCLHb) as an alternative to blood transfusion in cardiac surgery patients following cardiopulmonary bypass: A pivotal efficacy trial. [J].
Baron, JF ;
Berridge, J ;
Brichant, JF ;
Demeyere, R ;
Lamy, M ;
Larbuisson, R ;
Lehot, JJ ;
Parsloe, M ;
Sinclair, CJ ;
Vandermeersch, E .
ANESTHESIOLOGY, 1997, 87 (03) :A217-A217
[2]   IMMEDIATE VERSUS DELAYED FLUID RESUSCITATION FOR HYPOTENSIVE PATIENTS WITH PENETRATING TORSO INJURIES [J].
BICKELL, WH ;
WALL, MJ ;
PEPE, PE ;
MARTIN, RR ;
GINGER, VF ;
ALLEN, MK ;
MATTOX, KL .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (17) :1105-1109
[3]  
BLEEKER WK, 1989, J LAB CLIN MED, V113, P151
[4]  
DeAngeles DA, 1997, J TRAUMA, V42, P406, DOI 10.1097/00005373-199703000-00007
[5]   Human haemoglobin from transgenic tobacco [J].
Dieryck, W ;
Pagnier, J ;
Poyart, C ;
Marden, MC ;
Gruber, V ;
Bournat, P ;
Baudino, S ;
Merot, B .
NATURE, 1997, 386 (6620) :29-30
[6]   The effects of cross-linked hemoglobin on regional vascular conductance in dogs [J].
Dietz, NM ;
Martin, CM ;
BeltrandelRio, AG ;
Joyner, MJ .
ANESTHESIA AND ANALGESIA, 1997, 85 (02) :265-273
[7]   Effect of progressive haemodilution with hydroxyethyl starch, gelatin and albumin on blood coagulation [J].
Egli, GA ;
Zollinger, A ;
Seifert, B ;
Popovic, D ;
Pasch, T ;
Spahn, DR .
BRITISH JOURNAL OF ANAESTHESIA, 1997, 78 (06) :684-689
[8]   Transfusing red blood cells stored in citrate phosphate dextrose adenine-1 for 28 days fails to improve tissue oxygenation in rats [J].
Fitzgerald, RD ;
Martin, CM ;
Dietz, GE ;
Doig, GS ;
Potter, RF ;
Sibbald, WJ .
CRITICAL CARE MEDICINE, 1997, 25 (05) :726-732
[9]   Clinical utility of human polymerized hemoglobin as a blood substitute after acute trauma and urgent surgery [J].
Gould, SA ;
Moore, EE ;
Moore, FA ;
Haenel, JB ;
Burch, JM ;
Sehgal, H ;
Sehgal, L ;
DeWoskin, R ;
Moss, GS .
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1997, 43 (02) :325-331
[10]  
Gould SA, 1996, WORLD J SURG, V20, P1200