Current status of artificial oxygen carriers

被引:54
作者
Spahn, DR [1 ]
机构
[1] Univ Zurich Hosp, Inst Anasthesiol, CH-8091 Zurich, Switzerland
关键词
artificial oxygen carriers; oxygen transport; hemoglobin solutions; fluorocarbon emulsion; perflubron;
D O I
10.1016/S0169-409X(99)00046-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Artificial oxygen carriers may be grouped into modified hemoglobin solutions and fluorocarbon emulsions. In animal experiments, both have been shown to be efficacious in improving tissue oxygenation and as substitutes for blood transfusions. Advantages and disadvantages are being discussed in this article as well as the latest steps in the clinical development. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:143 / 151
页数:9
相关论文
共 51 条
[21]  
Kasper SM, 1996, ANESTH ANALG, V83, P921
[22]  
KEIPERT PE, 1994, J LAB CLIN MED, V123, P701
[23]  
Keipert PE, 1998, TISS ENG, P127
[24]  
KEIPERT PE, 1994, ADV EXP MED BIOL, V345, P197
[25]  
Keipert PE, 1996, ADV EXP MED BIOL, V388, P603
[26]   REDUCTION OF MYOCARDIAL-ISCHEMIA DURING PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY WITH OXYGENATED FLUOSOL [J].
KENT, KM ;
CLEMAN, MW ;
COWLEY, MJ ;
FORMAN, MB ;
JAFFE, CC ;
KAPLAN, M ;
KING, SB ;
KRUCOFF, MW ;
LASSAR, T ;
MCAULEY, B ;
SMITH, R ;
WISDOM, C ;
WOHLGELERNTER, D .
AMERICAN JOURNAL OF CARDIOLOGY, 1990, 66 (03) :279-284
[27]   A HUMAN RECOMBINANT HEMOGLOBIN DESIGNED FOR USE AS A BLOOD SUBSTITUTE [J].
LOOKER, D ;
ABBOTTBROWN, D ;
COZART, P ;
DURFEE, S ;
HOFFMAN, S ;
MATHEWS, AJ ;
MILLERROEHRICH, J ;
SHOEMAKER, S ;
TRIMBLE, S ;
FERMI, G ;
KOMIYAMA, NH ;
NAGAI, K ;
STETLER, GL .
NATURE, 1992, 356 (6366) :258-260
[28]  
Ma ZM, 1997, CLIN CHEM, V43, P1732
[29]   Selective aortic arch perfusion during cardiac arrest: Enhanced resuscitation using oxygenated perflubron emulsion, with and without aortic arch epinephrine [J].
Manning, JE ;
Batson, DN ;
Payne, FB ;
Adam, N ;
Murphy, CA ;
Perretta, SG ;
Norfleet, EA .
ANNALS OF EMERGENCY MEDICINE, 1997, 29 (05) :580-587
[30]   Absence of immunogenicity of diaspirin cross-linked hemoglobin in humans [J].
Patel, MJ ;
Webb, EJ ;
Shelbourn, TE ;
Mattia-Goldberg, C ;
George, AJT ;
Zhang, F ;
Moore, EG ;
Nelson, DJ .
BLOOD, 1998, 91 (02) :710-716