Development of antiinflammatory therapy for Alzheimer's disease

被引：5

作者：

Aisen, PS

机构：

[1] Georgetown Univ, Med Ctr, Dept Neurol, Memory Disorders Program, Washington, DC 20007 USA

[2] Georgetown Univ, Med Ctr, Dept Med, Memory Disorders Program, Washington, DC 20007 USA

来源：

DRUG DEVELOPMENT RESEARCH | 2002年 / 56卷 / 03期

关键词：

Alzheimer's disease; inflammation; therapeutic trials; nonsteroidal anti inflammatory drugs;

D O I：

10.1002/ddr.10094

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inflammatory mechanisms are active in the Alzheimer's disease (AD) brain. Studies that range from epidemiological surveys to therapeutic trials in transgenic mice provide growing support for the theory that anti inflammatory drugs may be useful in the prevention and/or treatment of the disease. Randomized controlled trials in humans have not yet confirmed this theory. However, prevention and treatment trials continue to test specific anti inflammatory strategies for AD.

引用

页码：421 / 427

页数：7

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