Capsaicin Inhibits Dimethylnitrosamine-Induced Hepatic Fibrosis by Inhibiting the TGF-β1/SmadPathway via Peroxisome Proliferator-Activated Receptor Gamma Activation

被引：74

作者：

Choi, Jae Ho ^{[1
]}

Jin, Sun Woo ^{[1
]}

Choi, Chul Yung ^{[2
]}

Kim, Hyung Gyun ^{[1
,4
]}

Lee, Gi Ho ^{[1
]}

Kim, Yong An ^{[1
]}

Chung, Young Chul ^{[3
]}

Jeong, Hye Gwang ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea

[2] Jeollanamdo Inst Nat Resources Res, Jeollanamdo, South Korea

[3] Int Univ Korea, Dept Food Sci, Jinju, South Korea

[4] Mokpo Marine Food Ind Res Ctr, Dept Res Planning Team, Mokpo, South Korea

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2017年 / 65卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

INDUCED LIVER FIBROSIS; NF-KAPPA-B; STELLATE CELLS; EXTRACELLULAR-MATRIX; CARBON-TETRACHLORIDE; DIETARY CAPSAICIN; OXIDATIVE STRESS; NATURAL-PRODUCTS; PPAR-GAMMA; TNF-ALPHA;

D O I：

10.1021/acs.jafc.6b04805

中图分类号：

S [农业科学];

学科分类号：

082806 [农业信息与电气工程];

摘要：

Capsaicin (CPS) exerts many pharmacological effects, but any possible influence On liver fibrosis remains unclear. Therefore, we, evaluated the inhibitory effects of CPS on dimethylnitrosamine (DMN) and TGF-beta 1-induced liver fibrosis in rats and hepatic stellate cells (HSCs). CPS inhibited DMN-induced hepatotoxicity, NF-kB activation, and collagen accumulation. CPS also suppressed the DMN-induced increases in alpha-SMA, collagen type I, MMP-2, and TNF-alpha In addition, CPS inhibited DMN-induced TGF-beta 1 expression (from 2.3 +/- 0.1 to 1.0 +/- 0.1) and Smad2/3 phosphorylation (from 1.5 +/- 0.1 to 1.1 +/- 0.1 and from 1.6 +/- 0.1 to 1.1 +/- 0.1, respectively) by activating Smad7 expression (from 0.1 +/- 0.0 to 0.9 +/- 0.1)via PPAR-y induction (from 0.2 +/- 0:0 to 0.8 +/- 0.0) (p < 0.05). Furthermore, in HSCs, CPS inhibited the TGF-beta 1-induced increases in alpha-SMA and collagen. type I expression, via PPAR-y activation. These results indicate that CPS can ameliorate ]hepatic fibrosis-by inhibiting the TGP-beta 1/Smad pathway via PPAR-y activation.

引用

页码：317 / 326

页数：10

共 42 条

[1]

Inhibitory effect of dietary capsaicin on liver fibrosis in mice [J].