Enantioselective hydrogenation of aromatic ketones catalyzed by Ru complexes of Goodwin-Lions-type sp2N/sp3N hybrid Ligands R-BINAN-R′-Py

被引：104

作者：

Huang, Hanmin

Okuno, Tomoko

Tsuda, Kazuomi

Yoshimura, Masahiro

Kitamura, Masato ^{[1
]}

机构：

[1] Nagoya Univ, Res Ctr Mat Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[2] Nagoya Univ, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 27期

关键词：

D O I：

10.1021/ja062451a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Goodwin-Lions-type sp2N/sp3N hybrid ligands R-BINAN-R′-Py possessing a C2 axis binaphthyl skeleton have been designed and synthesized. Combination of the new non-phosphine ligand with Ru(π-CH2C(CH3)CH2)2(cod) has been revealed to catalyze the hydrogenation of aromatic ketones with high enantioselectivity of up to 99% ee. The reaction proceeds essentially without the need for any bases, but the reactivity is enhanced by the addition of KOt-C4H9 attaining an S/C ratio of up to 10000. The success should expand the range of possibilities in designing catalysts not only for hydrogenation but also for many other reactions. Copyright © 2006 American Chemical Society.

引用

页码：8716 / 8717

页数：2

共 32 条

[11] Origin of the minor enantiomeric product in a noyori asymmetric hydrogenation: Evidence for pathways different to the major mechanism [J].