Ginkgolides: Selective acetylations, translactonization, and biological evaluation

被引：20

作者：

Jaracz, S ^{[1
]}

Stromgaard, K ^{[1
]}

Nakanishi, K ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 13期

关键词：

D O I：

10.1021/jo020139n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Protocols for selective acetylation of the hydroxyl groups of ginkgolide C have been developed. These acetylations have given rise to various ginkgolide C acetates and iso-ginkgolide C acetates, the latter having a rearranged skeleton resulting from translactonization. These acetyl derivatives, as well as ginkgolides A and B acetates have been investigated for their ability to bind to a cloned platelet-activating factor (PAF) receptor.

引用

页码：4623 / 4626

页数：4

共 22 条

[1] INTRAMOLECULAR AND INTERMOLECULAR HYDROXYL REACTIVITY DIFFERENCES IN GINKGOLIDE-A, GINKGOLIDE-B GINKGOLIDE-C AND THEIR CHEMICAL APPLICATIONS [J].