Synthesis of chitosan derivatives with quaternary ammonium salt and their antibacterial activity

被引:302
作者
Kim, CH [1 ]
Choi, JW [1 ]
Chun, HJ [1 ]
Choi, KS [1 ]
机构
[1] HANYANG UNIV,COLL ENGN,DEPT IND CHEM,SEOUL 133791,SOUTH KOREA
关键词
D O I
10.1007/s002890050064
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
N-alkyl chitosan derivatives were prepared by introducing alkyl groups into the amine groups of chitosan via Schiff's base intermediates. Quaternization of the N-alkyl chitosan derivatives were carried out using methyl iodide to produce water soluble cationic polyelectrolytes, novel chitosan derivatives with quaternary ammonium salt. Their antibacterial activities against S.aureus were explored by the viable cell counting method in acetate buffer(pH 6.0). The antibacterial activities of the chitosan derivatives with quaternary ammonium salt increased with increase in the chain length of the alkyl substituent, and this increased activity could be ascribed to the contribution of the increased hydrophobic properties of the derivatives.
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页码:387 / 393
页数:7
相关论文
共 21 条
[1]   SYNTHESIS OF CHITIN DERIVATIVES AND THEIR METAL-COMPLEXES [J].
CHOI, KS .
MAKROMOLEKULARE CHEMIE-MACROMOLECULAR SYMPOSIA, 1990, 33 :55-63
[2]   NEW METHOD FOR THE QUATERNIZATION OF CHITOSAN [J].
DOMARD, A ;
RINAUDO, M ;
TERRASSIN, C .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1986, 8 (02) :105-107
[3]   C-13 AND H-1-NMR SPECTROSCOPY OF CHITOSAN AND N-TRIMETHYL CHLORIDE DERIVATIVES [J].
DOMARD, A ;
GEY, C ;
RINAUDO, M ;
TERRASSIN, C .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1987, 9 (04) :233-237
[4]  
DYSON RD, 1978, CELL BIOL, P70
[5]   ANTIFUNGAL ACTIVITY OF CHITOSAN AND ITS PRESERVATIVE EFFECT ON LOW-SUGAR CANDIED KUMQUAT [J].
FANG, SW ;
LI, CF ;
SHIH, DYC .
JOURNAL OF FOOD PROTECTION, 1994, 57 (02) :136-+
[6]  
FRANKLIN TJ, 1981, BIOCH ANTIMICRIBIAL
[7]  
HATTA SADAYOSHI, 1950, JAPANESE MED JOUR, V3, P119
[8]   THE STABILITY AND PROPERTIES OF BIMOLECULAR LIPID LEAFLETS IN AQUEOUS SOLUTIONS [J].
HAYDON, DA ;
TAYLOR, J .
JOURNAL OF THEORETICAL BIOLOGY, 1963, 4 (03) :281-296
[9]  
IKEDA T, 1984, MAKROMOL CHEM, V185, P869
[10]   POLYCATIONIC BIOCIDES WITH PENDANT ACTIVE GROUPS - MOLECULAR-WEIGHT DEPENDENCE OF ANTIBACTERIAL ACTIVITY [J].
IKEDA, T ;
HIRAYAMA, H ;
YAMAGUCHI, H ;
TAZUKE, S ;
WATANABE, M .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (01) :132-136