Highly enantioselective alkynylation of aldehydes catalyzed by a readily available chiral amino alcohol-based ligand

被引：125

作者：

Jiang, B ^{[1
]}

Chen, ZL ^{[1
]}

Xiong, WN ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 14期

关键词：

D O I：

10.1039/b203984b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new inexpensive chiral amino alcohol-based ligand, (1S,2S)-2-N, N-dimethylamino-1-(p-nitrophenyl)-3-(t-butyldimethylsilyloxy) propane-1-ol, was developed for the asymmetric alkynylation of aliphatic and aromatic aldehydes, to prepare the corresponding propargylic alcohols in high yields with up to 99% ee.

引用

页码：1524 / 1525

页数：2

共 25 条

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