Progress towards the total synthesis of callipeltin A.: Asymmetric synthesis of (2R,3R,4S)-3-hydroxy-2,4,6-trimethylheptanoic acid

被引：45

作者：

Guerlavais, V ^{[1
]}

Carroll, PJ ^{[1
]}

Joullié, MM ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 07期

关键词：

D O I：

10.1016/S0957-4166(02)00045-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A silyl derivative of (2R,3R,4S)-3-hydroxy-2,4,6-trimethylheptanoic acid, a moiety present in the cyclic depsipeptide callipeltin A, was successfully synthesized from L-valine in nine steps using the Heathcock variant of the Evans aldol reaction. (C) 2002 Published by Elsevier Science Ltd.

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页码：675 / 680

页数：6

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