Intracellular trafficking of Notch receptors and ligands

被引：33

作者：

Brou, Christel ^{[1
]}

机构：

[1] Inst Pasteur, Unite Signalisat Mol & Activat Cellulaire, URA 2582, CNRS, F-75724 Paris 15, France

来源：

EXPERIMENTAL CELL RESEARCH | 2009年 / 315卷 / 09期

关键词：

Notch signaling; DSL ligands; Endocytosis; Ubiquitination; SPECIFY CELL FATE; DROSOPHILA-MELANOGASTER; PROTEOLYTIC ACTIVATION; SIGNALING ACTIVITY; DELTA-ENDOCYTOSIS; CLEAVAGE; PROTEIN; DOMAIN; MEMBRANE; PATHWAY;

D O I：

10.1016/j.yexcr.2008.09.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Notch pathway represents a highly conserved signaling network, which regulates the formation and maintenance of various organ systems along development and during adulthood. Direct cell-cell contacts between ligand- and receptor-expressing cells underlie activation of the Notch pathway. Notch signaling requires endocytosis in both signal emitting and receiving cells. Recent findings on the roles of a number of modulators show that they act either on the maintenance of an active receptor at the membrane, or on the production of active ligand, or on signal transduction after activation. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1549 / 1555

页数：7

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