Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum

被引：62

作者：

Ishiuchi, Kan'ichiro

Kubota, Takaaki

Hoshino, Tomohiro

Obara, Yutaro

Nakahata, Norimichi

Kobayashi, Jun'ichi ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 17期

关键词：

Lycopodium alkaloids; lycopladines B-D; lyconadin B; NGF expression; astrocytoma cells;

D O I：

10.1016/j.bmc.2006.05.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new alkaloids, lycopladines B-D (1-3) and lyconadin B (4), have been isolated from the club moss Lycopodium complanatum and the structures including the stereochemistry were elucidated on the basis of spectral data and modified Mosher's method. Lyconadin B (4) elevated NGF mRNA expression in 1321N1 human astrocytoma cells. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5995 / 6000

页数：6

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