Abdominal aortic aneurysms: Cost-effectiveness of elective endovascular and open surgical repair

PURPOSE: To evaluate :the cost-effectiveness of elective enclovascular and open surgical repair of infrarenal abdominal aortic aneurysms (AAAs) by taking into account short- and long-term outcomes. MATERIALS AND METHODS: A Markov decision model was developed to evaluate quality-adjusted life-years (QALYs) and lifetime costs of enclovascular and open surgical repair. The incremental cost-effectiveness ratio (CER) was calculated for enclovascular repair relative to open surgery in a cohort of 70-year-old men with an AAA between 5 and 6 m in diameter. Clinically effectiveness data were derived from the literature. Cost data were derived from Medicare reimbursement rates, the literature. One- and multiple-way sensitivity analyses were performed on. uncertain model parameters. Costs were converted to year 2000 U.S. dollars; future costs band outcomes were discounted at 3%. RESULTS: The incremental CER of enclovascular repair was $9,905 per QALY. QALYs and lifetime costs were higher for enclovascular repair than for open surgery (6.74 vs 6.52 and $39,785 vs $37;606,- respectively). In sensitivity analyses, the incremental CER was insensitive to immediate conversion rate and procedure mortality rate. The incremental CER was sensitive (ie, more than $75,000 per QALY or enclovascular repair was ruled out by dominance) to systemic-remote complications, long-term failures, and ruptures. CONCLUSION: The, results suggest that enclovascular repair is a cost-effective alternative compared with open surgery for the elective repair of AAA. The benefits and cost-effectiveness are highly dependent on uncertain outcomes, however, particularly long-term, failure and rupture rates.