Antigen presentation by dendritic cells in vivo

被引：127

作者：

Segura, Elodie ^{[1
,2
]}

Villadangos, Jose A. ^{[2
]}

机构：

[1] INSERM, U932, F-75005 Paris, France

[2] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 01期

基金：

英国医学研究理事会;

关键词：

LANGERHANS CELLS; T-CELLS; CROSS-PRESENTATION; CD8; EXPRESSION; CUTTING EDGE; MOUSE THYMUS; INFECTION; POPULATIONS; DISTINCT; CD4(+);

D O I：

10.1016/j.coi.2009.03.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DC) are heterogenous, comprising several subpopulations of migratory and lymphoid-organ-resident types. Recent studies addressing the role of each subset in antigen presentation in vivo have revealed a complex division of labor within the DC network. In addition to CD8(+) DC, migratory lung or dermal DC can cross-present antigen in vivo. Migratory DC also transport to the lymph nodes antigens that can be transferred to resident DC for presentation. In inflammatory conditions, the antigen-presentation abilities of DC can be severely impaired, but an additional population of monocyte-derived DC then comes into play. Understanding the contribution of each DC subset to a physiological immune response is particularly relevant for rational vaccine design.

引用

页码：105 / 110

页数：6

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