Putative projection of phrenic afferents to the limbic cortex in humans studied with cerebral-evoked potentials

被引:29
作者
Straus, C
Zelter, M
Derenne, JP
Pidoux, B
Willer, JC
Similowski, T
机构
[1] GRP HOSP PITIE SALPETRIERE, SERV PNEUMOL & REANIMAT, PHYSIOL RESP LAB, SERV PNEUMOL, F-75651 PARIS 13, FRANCE
[2] GRP HOSP PITIE SALPETRIERE, SERV CENT EXPLORAT FONCTIONNELLES RESP, F-75651 PARIS, FRANCE
[3] GRP HOSP PITIE SALPETRIERE, SERV EXPLORAT FONCTIONNELLES SYST NERVEUX, F-75651 PARIS 13, FRANCE
关键词
phrenic nerve; diaphragm; cerebral cortex; respiratory afferents; control of breathing; dyspnea;
D O I
10.1152/jappl.1997.82.2.480
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Respiratory tory sensations may rely in part on cortical integration of respiratory afferent information. In an attempt to study such projections, we recorded evoked potentials at scalp and cervical sites in 10 normal volunteers undergoing transcutaneous phrenic stimulation (0.1-ms square pulses, intensity liminal for diaphragmatic activation, series of 600 shocks at 2 Hz). A negative cerebral component of peak latency (12.79 +/- 0.54 ms; N13) was constant, and a negative spinal component (7.09 +/- 1.04 ms; N7) could also be recorded, all results being reproducible over time. Monitoring of cardiac frequency, skin anesthesia, and stimulation adjacent to the phrenic nerve made the phrenic origin of N7 and N13 the foremost hypothesis. Increasing stimulation frequency and comparison with median nerve stimulation provided arguments for the neural nature of the signals and their cerebral origin. Recordings from intracerebral electrodes in a patient showed a polarity reversal of the evoked potentials at the level of the cingulate gyrus. In conclusion, phrenic stimulation could allow one to study projections of phrenic afferents to the central nervous system in humans. Their exact site and physiological meaning remain to be clarified.
引用
收藏
页码:480 / 490
页数:11
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