Synthesis and 12-helical secondary structure of β-peptides containing (2R,3R)-aminoproline

被引：44

作者：

Porter, EA ^{[1
]}

Wang, XF ^{[1
]}

Schmitt, MA ^{[1
]}

Gellman, SH ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 19期

关键词：

D O I：

10.1021/ol0266370

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(2R,3R)-Aminoproline, A pyrrolidine-based beta-amino acid, was synthesized and incorporated into hexa-beta-peptide 4. This residue confers water solubility when the ring nitrogen is protonated and allows for 12-helix formation in aqueous solution. Circular dichroism spectra display the 12-helical signature, and 12-helical structure was confirmed by 2D NMR analysis.

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页码：3317 / 3319

页数：3

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