External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study

被引：8

作者：

Almagro, Pere ^{[1
]}

Martinez-Camblor, Pablo ^{[2
]}

Miravitlles, Marc ^{[3
]}

Rodriguez Carballeira, Monica ^{[1
]}

Navarro, Annie ^{[4
]}

Lamprecht, Bernd ^{[5
,6
]}

Ramirez-Garcia Luna, Ana S. ^{[7
]}

Kaiser, Bernhard ^{[8
]}

Alfageme, Inmaculada ^{[9
]}

Casanova, Ciro ^{[10
]}

Esteban, Cristobal ^{[11
]}

Soler-Cataluna, Juan J. ^{[12
]}

de-Torres, Juan P. ^{[13
]}

Celli, Bartolome R. ^{[14
]}

Marin, Jose M. ^{[15
,16
]}

ter Riet, Gerben ^{[17
]}

Sobradillo, Patricia ^{[18
,19
]}

Lange, Peter ^{[20
]}

Garcia-Aymeric, Judith ^{[21
,22
,23
]}

Anto, Josep M. ^{[21
,22
,23
]}

Turner, Alice M. ^{[24
]}

Han, MeiLan K. ^{[25
]}

Langhammer, Arnulf ^{[26
]}

Sternberg, Alice ^{[27
]}

Leivseth, Linda ^{[28
]}

Bakke, Per ^{[29
]}

Johannessen, Ane ^{[30
]}

Oga, Toru ^{[31
]}

Cosio, Borja ^{[32
]}

Ancochea, Julio ^{[33
]}

Echazarreta, Andres ^{[34
]}

Roche, Nicolas ^{[35
]}

Burgel, Pierre-Regis ^{[36
]}

Sin, Don D. ^{[36
,37
]}

Puhan, Milo A. ^{[38
]}

Soriano, Joan B. ^{[39
]}

机构：

[1] Univ Barcelona, Hosp Univ Mutua de Terrassa, Internal Med, Multimorbid Patients Unit, Barcelona, Spain

[2] Geisel Sch Med Dartmouth, Hanover, NH USA

[3] Hosp Univ Vall dHebron, CIBER Enfermedades Resp CIBERES, Pneumol Dept, Barcelona, Spain

[4] Hosp Univ Mutua Terrassa, Pneumol Serv, Barcelona, Spain

[5] Kepler Univ Hosp, Dept Pulm Med, Linz, Austria

[6] Johannes Kepler Univ Linz, Fac Med, Linz, Austria

[7] Univ Autonoma San Luis Potosi, Fac Med, San Luis Potosi, Mexico

[8] Paracelsus Med Univ Hosp, Dept Pulm Med, Salzburg, Austria

[9] Univ Seville, Dept Med, HU Virgen de Valme, Seville, Spain

[10] Univ La Laguna, Hosp Univ Nuestra Senora Candelaria, Tenerife, Spain

[11] Hosp Galdakao Usansolo, Galdakao, Bizkaia, Spain

[12] Hosp Arnau Vilanova, Serv Neumol, Valencia, Spain

[13] Clin Univ Navarra, Pamplona, Spain

[14] Harvard Univ, Brigham & Womens Hosp, Pulm & Crit Care Med, Boston, MA 02115 USA

[15] Hosp Univ Miguel Servet, Zaragoza, Spain

[16] CIBER Enfermedades Resp CIBERES, Barcelona, Spain

[17] Univ Amsterdam AMC, Acad Med Ctr, Dept Gen Practice, Amsterdam, Netherlands

[18] Hosp Univ Araba, Sede Txagorritxu, Vitoria, Spain

[19] Univ Hosp Cruces, Baracaldo, Spain

[20] Univ Copenhagen, Copenhagen City Heart Study, Frederiksberg Hosp, Dept Publ Hlth,Sect Social Med, Copenhagen, Denmark

[21] Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain

[22] UPF, Dept Expt & Hlth Sci, Barcelona, Spain

[23] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain

[24] Univ Birmingham, Inst Appl Hlth Res, Edgbaston, England

[25] Univ Michigan, Div Pulm & Crit Care Med, Internal Med, Ann Arbor, MI 48109 USA

[26] Norwegian Univ Sci & Technol, NTNU, Dept Publ Hlth & Nursing, Trondheim, Norway

[27] Johns Hopkins Univ, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA

[28] Northern Norway Reg Hlth Author, Ctr Clin Documentat & Evaluat, Tromso, Norway

[29] Univ Bergen, Dept Clin Sci, Bergen, Norway

[30] Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway

[31] Kyoto Univ, Dept Resp Care & Sleep Control Med, Kyoto, Japan

[32] Hosp Son Espases IdISPa, Dept Resp Med, Ciberes, Mallorca, Spain

[33] Univ Autonoma Madrid, Catedra UAM Linde, Hosp Univ Princesa IISP, Serv Neumol, Madrid, Spain

[34] Hosp San Juan de Dios La Plata, Serv Neumonol, Buenos Aires, DF, Argentina

[35] Univ Paris 05, Cochin Hosp, AP HP, Resp Med, Paris, France

[36] Univ British Columbia, James Hogg Res Ctr, Vancouver, BC, Canada

[37] St Pauls Hosp, Dept Med, Div Resp Med, Vancouver, BC, Canada

[38] Univ Zurich, Epidemiol Biostat & Prevent Inst, Zurich, Switzerland

[39] Univ Autonoma Madrid, Catedra UAM Linde, Inst Invest Hosp Univ Princesa IISP, Madrid, Spain

来源：

COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2019年 / 16卷 / 01期

关键词：

Prognosis; COPD; mortality; survival; multicomponent index; comorbidities; HOSPITAL MORTALITY; PROGNOSTIC ASSESSMENT; AIRWAY-OBSTRUCTION; ACUTE EXACERBATION; DECAF SCORE; BODE INDEX; SURVIVAL; DYSPNEA; PREDICTOR; IMPACT;

D O I：

10.1080/15412555.2018.1484440

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

The CODEX index was developed and validated in patients hospitalized for COPD exacerbation to predict the risk of death and readmission within one year after discharge. Our study aimed to validate the CODEX index in a large external population of COPD patients with variable durations of follow-up. Additionally, we aimed to recalculate the thresholds of the CODEX index using the cutoffs of variables previously suggested in the 3CIA study (mCODEX).Individual data on 2,755 patients included in the COPD Cohorts Collaborative International Assessment Plus (3CIA+) were explored. A further two cohorts (ESMI AND EGARPOC-2) were added. To validate the CODEX index, the relationship between mortality and the CODEX index was assessed using cumulative/dynamic ROC curves at different follow-up periods, ranging from 3 months up to 10 years. Calibration was performed using univariate and multivariate Cox proportional hazard models and Hosmer-Lemeshow test.A total of 3,321 (87.8% males) patients were included with a meanSD age of 66.9 +/- 10.5 years, and a median follow-up of 1,064 days (IQR 25-75% 426-1643), totaling 11,190 person-years. The CODEX index was statistically associated with mortality in the short- (3 months), medium- (1 year) and long-term (10 years), with an area under the curve of 0.72, 0.70 and 0.76, respectively. The mCODEX index performed better in the medium-term (<1 year) than the original CODEX, and similarly in the long-term.In conclusion, CODEX and mCODEX index are good predictors of mortality in patients with COPD, regardless of disease severity or duration of follow-up.

引用

页码：8 / 17

页数：10

共 47 条

[1]

Almagro P, 2017, INT J CHRONIC OBSTR, V12, P1005

[2]

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