Tissue-resident memory T cells at the center of immunity to solid tumors

被引：245

作者：

Amsen, Derk ^{[1
]}

van Gisbergen, Klaas P. J. M. ^{[1
]}

Hombrink, Pleun ^{[1
]}

van Lier, Rene A. W. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Hematopoiesis, Sanquin Res & Landsteiner Lab, Amsterdam, Netherlands

来源：

NATURE IMMUNOLOGY | 2018年 / 19卷 / 06期

关键词：

LYTIC GRANULE POLARIZATION; INFILTRATING LYMPHOCYTES; DENDRITIC CELLS; TGF-BETA; NONLYMPHOID TISSUES; CYTOTOXIC FUNCTION; LOCAL ANTIGEN; CUTTING EDGE; RM CELLS; CD103;

D O I：

10.1038/s41590-018-0114-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Immune responses in tissues are constrained by the physiological properties of the tissue involved. Tissue-resident memory T cells (T-RM cells) are a recently discovered lineage of T cells specialized for life and function within tissues. Emerging evidence has shown that T-RM cells have a special role in the control of solid tumors. A high frequency of T-RM cells in tumors correlates with favorable disease progression in patients with cancer, and studies of mice have shown that T-RM cells are necessary for optimal immunological control of solid tumors. Here we describe what defines T-RM cells as a separate lineage and how these cells are generated. Furthermore, we discuss the properties that allow T-RM cells to operate in normal and transformed tissues, as well as implications for the treatment of patients with cancer.

引用

页码：538 / 546

页数：9

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