Molecular characteristics of mammalian dopamine receptors

被引：106

作者：

Lachowicz, JE

Sibley, DR

机构：

[1] NINCDS, MOL NEUROPHARMACOL SECT, EXPT THERAPEUT BRANCH, NIH, BETHESDA, MD 20892 USA

[2] INDIANA UNIV, SCH MED, DEPT PEDIAT, NEUROENDOCRINE SECT, INDIANAPOLIS, IN 46202 USA

来源：

PHARMACOLOGY & TOXICOLOGY | 1997年 / 81卷 / 03期

关键词：

D O I：

10.1111/j.1600-0773.1997.tb00039.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dopamine receptors belong to a large super-gene family of receptors which are linked to their signal transduction pathways through heterotrimeric G proteins. A variety of signalling events are known to be regulated by dopamine receptors including adenylate cyclase and phospholipase activities and various ion channels. Prior to the advent of molecular cloning technology, dopamine receptors were believed to belong to two subtypes, D-1 and D-2 This distinction was based on both pharmacological and functional criteria. We now know that at least five different dopamine receptors exist although they can still be described as to belonging within ''D-1'' and ''D-2'' subfamilies. The D-1 subfamily consists of two receptors - the D-1 and D-5, whereas the D-2, D-3 and D-4 receptors comprise the D-2 subfamily. The cloning and molecular characteristics of these five receptors are described in this review.

引用

页码：105 / 113

页数：9

共 101 条

[1] A targeted mutation of the D-3 dopamine receptor gene is associated with hyperactivity in mice [J].