blaOXA-51-type β-lactamase genes are ubiquitous and vary within a strain in Acinetobacter baumannii

被引：74

作者：

Merkier, Andrea Karina ^{[1
]}

Centron, Daniela ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Med, Dept Microbiol Parasitol & Inmunol, Buenos Aires, DF, Argentina

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2006年 / 28卷 / 02期

关键词：

(bla)OXA-51-type genes; Acinetobacter baumannii; carbapenemases;

D O I：

10.1016/j.ijantimicag.2006.03.023

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We investigated the spread of bla(OXA-51)-type beta-lactamase genes in 200 Acinetobacter spp. clinical strains isolated in Argentina from 1982 to 2005. bla(OXA-51)-type genes were present in all Acinetobacter baumannii isolates tested (n = 194), whereas they were not detected in two Acinetobacter haemolyticus, two genomic species 10 or two Acinetobacter lwoffii isolates. The bla(OXA-51)-type alleles varied within a strain and were found in six different A. baumannii pulsed-field gel electrophoresis clones that were susceptible or resistant to imipenem, suggesting a controversial role in imipenem resistance. Our findings agree with previous reports showing that bla(OXA-51)-type genes are naturally harboured by A. baumannii isolates from various geographical origins and support the presence of a direct reservoir of beta-lactam resistance genes within the nosocomial environment. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：110 / 113

页数：4

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