Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease

被引:219
作者
Mielke, M. M. [1 ]
Kozauer, N. A.
Chan, K. C. G. [4 ]
George, M. [2 ]
Toroney, J. [2 ]
Zerrate, M. [2 ]
Bandeen-Roche, K. [4 ]
Wang, M. -C. [4 ]
vanZijl, P. [3 ,5 ]
Pekar, J. J. [3 ,5 ]
Mori, S. [3 ,5 ]
Lyketsos, C. G.
Albert, M. [2 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Psychiat, Div Geriatr Psychiat & Behav Sci, Baltimore, MD 21224 USA
[2] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21224 USA
[3] Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21224 USA
[4] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD 21224 USA
[5] Johns Hopkins Univ, Kennedy Kreiger Inst, FM Kirby Ctr Brain Imaging, Baltimore, MD 21224 USA
关键词
WHITE-MATTER DAMAGE; TRACT INTEGRITY; FIBER TRACTS; HIPPOCAMPAL; PATHOLOGY; DEMENTIA; SCALE; MRI;
D O I
10.1016/j.neuroimage.2009.01.054
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Diffusion tensor imaging (DTI) studies have shown significant cross-sectional differences among normal controls (NC) mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients in several fiber tracts in the brain, but longitudinal assessment is needed. Methods: We studied 75 participants (25 NC, 25 amnestic MCI, and 25 mild AD) at baseline and 3 months later, with both imaging and clinical evaluations. Fractional anisotropy (FA) was analyzed in regions of interest (ROIs) in: (1) fornix, (2) cingulum bundle, (3) splenium, and (4) cerebral peduncles. Clinical data included assessments of clinical severity and cognitive function. Cross-sectional and longitudinal differences in FA, within each ROI, were analyzed with generalized estimating equations (GEE). Results: Cross-sectionally, AD patients had lower FA than NC (p < 0.05) at baseline and 3 months in the fornix and anterior portion of the cingulum bundle. Compared to MCI, AD cases had lower FA (p < 0.05) in these regions and the splenium at 0 and 3 months. Both the fornix and anterior cingulum correlated across all clinical cognitive scores; lower FA in these ROIs corresponded to worse performance. Over the course of 3 months, when the subjects were clinically stable, the ROIs were also largely stable. Conclusions: Using DTI, findings indicate FA is decreased in specific fiber tracts among groups of subjects that vary along the spectrum from normal to AD, and that this measure is stable over short periods of time. The fornix is a predominant outflow tract of the hippocampus and may be an important indicator of AD progression. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:47 / 55
页数:9
相关论文
共 51 条
[1]   Diffusion-tensor MRI: theory, experimental design and data analysis - a technical review [J].
Basser, PJ ;
Jones, DK .
NMR IN BIOMEDICINE, 2002, 15 (7-8) :456-467
[2]   Changes in water diffusion due to wallerian degeneration in peripheral nerve [J].
Beaulieu, C ;
Does, MD ;
Snyder, RE ;
Allen, PS .
MAGNETIC RESONANCE IN MEDICINE, 1996, 36 (04) :627-631
[3]   Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions [J].
Bennett, DA ;
Schneider, JA ;
Bienias, JL ;
Evans, DA ;
Wilson, RS .
NEUROLOGY, 2005, 64 (05) :834-841
[4]  
Benton A., 1976, Multilingual aphasia examination
[5]   White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging [J].
Bozzali, M ;
Falini, A ;
Franceschi, M ;
Cercignani, M ;
Zuffi, M ;
Scotti, G ;
Comi, G ;
Filippi, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2002, 72 (06) :742-746
[6]  
Braak H, 1996, ACTA NEUROL SCAND, V93, P3
[7]   Abnormal integrity of corticocortical tracts in mild cognitive impairment: A diffusion tensor imaging study [J].
Cho, Hyun ;
Yang, Dong Won ;
Shon, Young Min ;
Kim, Beum Saeng ;
Kim, Yeong In ;
Choi, Young Bin ;
Lee, Kwang Soo ;
Shim, Yong Soo ;
Yoon, Bora ;
Kim, Woojin ;
Ahn, Kook Jin .
JOURNAL OF KOREAN MEDICAL SCIENCE, 2008, 23 (03) :477-483
[8]   Diffusion tensor imaging of frontal white matter microstructure in early Alzheimer's disease: A preliminary study [J].
Choi, SJ ;
Lim, KO ;
Monteiro, I ;
Reisberg, B .
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 2005, 18 (01) :12-19
[9]   THE NEUROPSYCHIATRIC INVENTORY - COMPREHENSIVE ASSESSMENT OF PSYCHOPATHOLOGY IN DEMENTIA [J].
CUMMINGS, JL ;
MEGA, M ;
GRAY, K ;
ROSENBERGTHOMPSON, S ;
CARUSI, DA ;
GORNBEIN, J .
NEUROLOGY, 1994, 44 (12) :2308-2314
[10]   Predicting conversion to Alzheimer disease using standardized clinical information [J].
Daly, E ;
Zaitchik, D ;
Copeland, M ;
Schmahmann, J ;
Gunther, J ;
Albert, M .
ARCHIVES OF NEUROLOGY, 2000, 57 (05) :675-680