Polysaccharide biological response modifiers

被引：418

作者：

Leung, M. Y. K.

Liu, C.

Koon, J. C. M.

Fung, K. P. ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China

来源：

IMMUNOLOGY LETTERS | 2006年 / 105卷 / 02期

关键词：

polysaccharide; biological response modifier; glucan; mannan; fucoidan; pectin; pattern recognition receptor;

D O I：

10.1016/j.imlet.2006.01.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Biological response modifiers (BRMs) are substances which augment immune response. BRMs can be cytokines which are produced endogenously in our body by immune cells or derivatives of bacteria, fungi, brown algae, Aloe very and photosynthetic plants. Such exogeneous derivatives (exogeneous BRMs) can be nucleic acid (CpG), lipid (lipotechoic acid), protein or polysaccharide in nature. The receptors for these exogeneous BRMs are pattern recognition receptors. The binding of exogeneous BRMs to pattern recognition receptors triggers immune response. Exogenous BRMs have been reported to have anti-viral, anti-bacterial, anti-fungal, anti-parasitic, and anti-tumor activities. Among different exogeneous BRMs, polysaccharide BRMs have the widest occurrence in nature. Some polysaccharide BRMs have been tested for their therapeutic properties in human clinical trials. An overview of current understandings of polysaccharide BRMs is summarized in this review. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：101 / 114

页数：14

共 228 条

[1] EFFECT OF LENTINAN AND MANNAN ON PHAGOCYTOSIS OF FLUORESCENT LATEX MICROBEADS BY MOUSE PERITONEAL-MACROPHAGES - A FLOW CYTOMETRIC STUDY [J].