Adipose tissue-mediated inflammation: the missing link between obesity and cardiovascular disease?

被引:61
作者
Calabro, Paolo [1 ]
Golia, Enrica [1 ]
Maddaloni, Valeria [1 ]
Malvezzi, Marco [1 ]
Casillo, Beniamino [1 ]
Marotta, Carla [2 ]
Calabro, Raffaele [1 ]
Golino, Paolo [1 ,2 ]
机构
[1] Univ Naples 2, Dept Cardiothorac Sci, Div Cardiol, Naples, Italy
[2] Univ Naples 2, San Sebastiano Hosp, Div Cardiol, Caserta, Italy
关键词
Obesity; Adipose tissue; Inflammation; Cardiovascular risk; C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; CONGENITAL LEPTIN DEFICIENCY; PLASMINOGEN-ACTIVATOR INHIBITOR-1; HEPATIC INSULIN-RESISTANCE; TYPE-2; DIABETES-MELLITUS; CORONARY-HEART-DISEASE; BODY-FAT MASS; WEIGHT-LOSS; FACTOR-ALPHA;
D O I
10.1007/s11739-008-0207-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Until relatively recently, the role of adipose tissue in the development of obesity and its consequences was considered to be a passive one. Mounting evidence highlights the role of adipose tissue in the development of a systemic inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular risk. It is now clear that, in addition to storing calories as triglycerides, adipocytes secrete a large variety of cytokines, chemokines and hormone-like factors, such as leptin, resistin, and acute-phase proteins. In addition, insulin resistance, both in nondiabetic and diabetic subjects, is frequently associated with obesity, particularly with an excess of intraabdominal fat. This production of pro-atherogenic substances is of particular interest since an increase in the plasma levels of these mediators may provide a novel mechanistic link between obesity and its vascular complications.
引用
收藏
页码:25 / 34
页数:10
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