Adipose tissue-mediated inflammation: the missing link between obesity and cardiovascular disease?

被引：61

作者：

Calabro, Paolo ^{[1
]}

Golia, Enrica ^{[1
]}

Maddaloni, Valeria ^{[1
]}

Malvezzi, Marco ^{[1
]}

Casillo, Beniamino ^{[1
]}

Marotta, Carla ^{[2
]}

Calabro, Raffaele ^{[1
]}

Golino, Paolo ^{[1
,2
]}

机构：

[1] Univ Naples 2, Dept Cardiothorac Sci, Div Cardiol, Naples, Italy

[2] Univ Naples 2, San Sebastiano Hosp, Div Cardiol, Caserta, Italy

来源：

INTERNAL AND EMERGENCY MEDICINE | 2009年 / 4卷 / 01期

关键词：

Obesity; Adipose tissue; Inflammation; Cardiovascular risk; C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; CONGENITAL LEPTIN DEFICIENCY; PLASMINOGEN-ACTIVATOR INHIBITOR-1; HEPATIC INSULIN-RESISTANCE; TYPE-2; DIABETES-MELLITUS; CORONARY-HEART-DISEASE; BODY-FAT MASS; WEIGHT-LOSS; FACTOR-ALPHA;

D O I：

10.1007/s11739-008-0207-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Until relatively recently, the role of adipose tissue in the development of obesity and its consequences was considered to be a passive one. Mounting evidence highlights the role of adipose tissue in the development of a systemic inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular risk. It is now clear that, in addition to storing calories as triglycerides, adipocytes secrete a large variety of cytokines, chemokines and hormone-like factors, such as leptin, resistin, and acute-phase proteins. In addition, insulin resistance, both in nondiabetic and diabetic subjects, is frequently associated with obesity, particularly with an excess of intraabdominal fat. This production of pro-atherogenic substances is of particular interest since an increase in the plasma levels of these mediators may provide a novel mechanistic link between obesity and its vascular complications.

引用

页码：25 / 34

页数：10

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