Measuring glomerular filtration rate in children; can cystatin C replace established methods? A review

被引:71
作者
Andersen, Trine Borup [1 ]
Eskild-Jensen, Anni [1 ]
Frokiaer, Jorgen [1 ]
Brochner-Mortensen, Jens [1 ]
机构
[1] Aarhus Univ Hosp, Dept Clin Physiol & Nucl Med, DK-9000 Aalborg, Denmark
关键词
Cystatin C; Creatinine; Glomerular filtration rate; Schwartz formula; Renal function; BETA-TRACE-PROTEIN; PLASMA CREATININE CONCENTRATION; HUMAN GAMMA-TRACE; SERUM CYSTATIN; RENAL-FUNCTION; KIDNEY-FUNCTION; THYROID-DYSFUNCTION; REFERENCE VALUES; INTRAINDIVIDUAL VARIATION; CORTICOSTEROID-THERAPY;
D O I
10.1007/s00467-008-0991-y
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Our aim was to evaluate published methods that use serum cystatin C (s-CysC) for measuring glomerular filtration rate (GFR) in children and to discuss advantages and limitations of s-CysC and of established GFR methods. A comprehensive literature review of clinical studies in children evaluating s-CysC or CysC-based formulas and plasma creatinine or creatinine-based formulas against an exogenous reference method using receiver operating characteristics (ROC) curves or Bland-Altman plots is presented. The comparison of s-CysC with plasma creatinine indicated that s-CysC was superior to plasma creatinine in five of 13 studies; four studies showed no difference, and, in four studies, no statistical comparison was made. Comparison of s-CysC and the Schwartz formula showed that s-CysC was superior to the Schwartz formula in two of seven studies; two studies demonstrated no difference, and, in one study, the Schwartz formula was superior to s-CysC. In two studies no statistical comparison was made. The CysC-based prediction equations all had high accuracy but low agreement when compared with a reference GFR, in the range of 30-40% at best. S-CysC is most likely superior to plasma creatinine and at least equal to creatinine-based formulas. CysC-based prediction equations are at least as good as creatinine-based formulas but cannot replace exogenous methods.
引用
收藏
页码:929 / 941
页数:13
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