Utilization of glycosyltransferases to change oligosaccharide structures

被引:25
作者
Guo, ZM [1 ]
Wang, PG [1 ]
机构
[1] UNIV MIAMI, DEPT CHEM, CORAL GABLES, FL 33124 USA
关键词
glycosyltransferase; sialyltransferase; galactosyltransferase; fucosyltransferase; N-acetylglucosaminyltransferase; oligosaccharide;
D O I
10.1007/BF02785977
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Carbohydrates on cell surfaces are important biomolecules in various biological recognition processes. Elucidation of the biological roles of complex oligosaccharides necessitates an efficient methodology to synthesize these compounds and their analogs. Enzymatic synthesis renders itself to be useful in the construction of an oligosaccharide structure owing to its mild reaction condition, high regio- and stereoselectivity. This review article focuses on the recent progress in oligosaccharide syntheses catalyzed by glycosyltransferases, namely sialyltransferase, galactosyltransferase, fucosyltransferase, and N-acetylglucosaminyltransferase. A survey of the latest patent and literature related to this field is also included.
引用
收藏
页码:1 / 20
页数:20
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