RuCl2(DMSO)4 catalyzes the β-alkylation of secondary alcohols with primary alcohols through a hydrogen autotransfer process

被引：148

作者：

Martinez, Ricardo

Ramon, Diego J.

Yus, Miguel

机构：

[1] Univ Alicante, Fac Ciencias, ISO, E-03080 Alicante, Spain

[2] Univ Alicante, Fac Ciencias, Dept Quim Organ, E-03080 Alicante, Spain

来源：

TETRAHEDRON | 2006年 / 62卷 / 38期

关键词：

D O I：

10.1016/j.tet.2006.07.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The electrophilic beta-alkylation of secondary alcohols with primary alcohols is accomplished by a hydrogen autotransfer process catalyzed by RUCl2(DMSO)(4). The reaction can produce either simple alkylated secondary alcohols or alpha,beta-unsaturated ketones with good to excellent results just by choosing the appropriate starting secondary alcohol (methyl or longer chain secondary alcohol, respectively), as well as quinolines (by using 2-aminobenzyl alcohol). (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：8982 / 8987

页数：6