Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents

被引：57

作者：

Rochais, C.

Lisowski, V.

Dallemagne, P.

Rault, S.

机构：

[1] Univ Caen, Ctr Etud & Rech Medicament Normandie, F-14032 Caen, France

[2] Fac Pharm Montpellier, F-34093 Montpellier 5, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 24期

关键词：

cyclization; pyrroles; fused-ring systems; L1210 murine leukemia cells;

D O I：

10.1016/j.bmc.2006.09.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We herein describe the synthesis of novel 3-(het)aryl-pyrrolo[2,3-b]pyrrolizin-8(1H)-ones starting from commercial (het)aryl-acetonitriles. A more convergent route was also described through the first synthesis of ethyl 3-amino-4-bromo-1H-pyrrole-2-carboxylate 17. The antiproliferative activities of these compounds were tested toward various cell lines and one of them 10k shows interesting cytotoxic properties, although it was less potent than our lead compound in thiophene series 1k. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：8162 / 8175

页数：14

共 14 条

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