Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease

被引：30

作者：

Wright, K ^{[1
]}

Guerreiro, C ^{[1
]}

Laurent, I ^{[1
]}

Baleux, F ^{[1
]}

Mulard, LA ^{[1
]}

机构：

[1] Inst Pasteur, Unite Chim Organ, CNRS, URA 2128, F-75724 Paris 15, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 10期

关键词：

D O I：

10.1039/b400986J

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of three neoglycopeptides incorporating carbohydrate haptens, differing in length, covalently linked to a non natural universal T helper peptide is disclosed. They were synthesized according to a blockwise strategy based on the condensation of appropriate di-, tri-, and tetrasaccharide trichloroacetimidate donors onto an azidoethyl 2-acetamido-2-deoxy-beta-D-glucopyranoside acceptor. Use of thiol-maleimide coupling chemistry allowed site-selective efficient conjugation.

引用

页码：1518 / 1527

页数：10

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