Human neocortical electrical activity recorded on nonpenetrating microwire arrays: applicability for neuroprostheses

被引：50

作者：

Kellis, Spencer S. ^{[2
]}

House, Paul A. ^{[1
]}

Thomson, Kyle E. ^{[3
]}

Brown, Richard ^{[2
]}

Greger, Bradley ^{[3
]}

机构：

[1] Univ Utah, Dept Neurosurg, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Elect & Comp Engn, Salt Lake City, UT USA

[3] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA

来源：

NEUROSURGICAL FOCUS | 2009年 / 27卷 / 01期

基金：

美国国家科学基金会;

关键词：

human; motor cortex; electrocorticoencephalography; neuroprosthesis; ELECTROCORTICOGRAPHIC SIGNALS; COMPUTER; DIRECTION;

D O I：

10.3171/2009.4.FOCUS0974

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Object. The goal of this study was to determine whether a nonpenetrating, high-density microwire array could provide sufficient information to serve as the interface for decoding motor cortical signals. Methods. Arrays of nonpenetrating microwires were implanted over the human motor cortex in 2 patients. The patients performed directed stereotypical reaching movements in 2 directions. The resulting data were used to determine whether the reach direction could be distinguished through a frequency power analysis. Results. Correlation analysis revealed decreasing signal correlation with distance. The gamma-band power during motor planning allowed binary classification of gross directionality in the reaching movements. The degree of power change was correlated to the underlying gyral pattern. Conclusions. The nonpenetrating microwire platform showed good potential for allowing differentiated signals to be recorded with high spatial fidelity without cortical penetration. (DOI:10.3171/2009.4.FOCUS0974)

引用

页数：9

共 15 条

[1] Online control of a brain-computer interface using phase synchronization [J].

Brunner, Clemens ;

Scherer, Reinhold ;

Graimann, Bernhard ;

Supp, Gemot ;

Pfurtscheller, Gert .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2006, 53 (12) :2501-2506

[2] Mapping of the preferred direction in the motor cortex [J].

Georgopoulos, Apostolos P. ;

Merchant, Hugo ;

Naselaris, Thomas ;

Amirikian, Bagrat .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (26) :11068-11072

[3] Neuronal ensemble control of prosthetic devices by a human with tetraplegia [J].

Hochberg, Leigh R. ;

Serruya, Mijail D. ;

Friehs, Gerhard M. ;

Mukand, Jon A. ;

Saleh, Maryam ;

Caplan, Abraham H. ;

Branner, Almut ;

Chen, David ;

Penn, Richard D. ;

Donoghue, John P. .

NATURE, 2006, 442 (7099) :164-171

[4] Direct control of a computer from the human central nervous system [J].

Kennedy, PR ;

Bakay, RAE ;

Moore, MM ;

Adams, K ;

Goldwaithe, J .

IEEE TRANSACTIONS ON REHABILITATION ENGINEERING, 2000, 8 (02) :198-202

[5] A brain-computer interface using electrocorticographic signals in humans [J].

Leuthardt, Eric C. ;

Schalk, Gerwin ;

Wolpaw, Jonathan R. ;

Ojemann, Jeffrey G. ;

Moran, Daniel W. .

JOURNAL OF NEURAL ENGINEERING, 2004, 1 (02) :63-71

[6] Cognitive control signals for neural prosthetics [J].

Musallam, S ;

Corneil, BD ;

Greger, B ;

Scherberger, H ;

Andersen, RA .

SCIENCE, 2004, 305 (5681) :258-262

[7] Encoding of movement direction in different frequency ranges of motor cortical local field potentials [J].

Rickert, J ;

de Oliveira, SC ;

Vaadia, E ;

Aertsen, A ;

Rotter, S ;

Mehring, C .

JOURNAL OF NEUROSCIENCE, 2005, 25 (39) :8815-8824

[8] Two-dimensional movement control using electrocorticographic signals in humans [J].

Schalk, G. ;

Miller, K. J. ;

Anderson, N. R. ;

Wilson, J. A. ;

Smyth, M. D. ;

Ojemann, J. G. ;

Moran, D. W. ;

Wolpaw, J. R. ;

Leuthardt, E. C. .

JOURNAL OF NEURAL ENGINEERING, 2008, 5 (01) :75-84

[9] Instant neural control of a movement signal [J].

Serruya, MD ;

Hatsopoulos, NG ;

Paninski, L ;

Fellows, MR ;

Donoghue, JP .

NATURE, 2002, 416 (6877) :141-142

[10] Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor cortex [J].

Suner, S ;

Fellows, MR ;

Vargas-Irwin, C ;

Nakata, GK ;

Donoghue, JP .

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, 2005, 13 (04) :524-541

← 1 2 →